A sleek white pump bottle of r-Retinoate Day & Night stands upright, with a swirl of white cream next to it.
A woman's face is shown with a small amount of white cream on their cheek. Four bullet points with checkmarks list benefits: Visibly brightens, revitalises & smooths the skin; For results 8x more powerful than retinol* – both day & night; Improves uneven skin tone & texture; and a 3-in-1 serum for a simplified regime.
A large white cylindrical airless pump dispenser bottle of Medik8 r-Retinoate® Day & Night stands vertically against a light grey minimalist background with subtle shadows. Text overlays on the left highlight its key features as a "3-In-1 LUXE SERUM": "ENCAPSULATED RETINYL RETINOATE 8x more powerful than retinol*" "STABILISED VITAMIN C For visible brightening & antioxidant power" "HYALURONIC ACID Hydrates & visibly plumps" A circular badge at the top right indicates "EXCLUSIVE TO Medik8".
A display showcasing THE R-RETINOATE RANGE. It includes, r-RETINOATE DAY & NIGHT EYE SERUM, r-RETINOATE DAY & NIGHT, r-RETINOATE INTENSE.
A HOW TO LAYER diagram for skincare routines. The AM routine includes Cleanse (Surface Radiance Cleanse), Tone (Press & Glow), Vitamin C + Vitamin A (r-Retinoate Day & Night), and Sunscreen (Advanced Day Total Protect). The PM routine involves Cleanse (Lipid-Balance Cleansing Oil), Tone (Press & Clear), Vitamin C + Vitamin A (r-Retinoate Day & Night), and Moisturise (Advanced Night Restore).
A sleek white pump bottle of r-Retinoate Day & Night stands beside its matching white carton
A sleek white pump bottle of r-Retinoate Day & Night stands upright, with a swirl of white cream next to it.
A woman's face is shown with a small amount of white cream on their cheek. Four bullet points with checkmarks list benefits: Visibly brightens, revitalises & smooths the skin; For results 8x more powerful than retinol* – both day & night; Improves uneven skin tone & texture; and a 3-in-1 serum for a simplified regime.
A large white cylindrical airless pump dispenser bottle of Medik8 r-Retinoate® Day & Night stands vertically against a light grey minimalist background with subtle shadows. Text overlays on the left highlight its key features as a "3-In-1 LUXE SERUM": "ENCAPSULATED RETINYL RETINOATE 8x more powerful than retinol*" "STABILISED VITAMIN C For visible brightening & antioxidant power" "HYALURONIC ACID Hydrates & visibly plumps" A circular badge at the top right indicates "EXCLUSIVE TO Medik8".
A display showcasing THE R-RETINOATE RANGE. It includes, r-RETINOATE DAY & NIGHT EYE SERUM, r-RETINOATE DAY & NIGHT, r-RETINOATE INTENSE.
A HOW TO LAYER diagram for skincare routines. The AM routine includes Cleanse (Surface Radiance Cleanse), Tone (Press & Glow), Vitamin C + Vitamin A (r-Retinoate Day & Night), and Sunscreen (Advanced Day Total Protect). The PM routine involves Cleanse (Lipid-Balance Cleansing Oil), Tone (Press & Clear), Vitamin C + Vitamin A (r-Retinoate Day & Night), and Moisturise (Advanced Night Restore).
A sleek white pump bottle of r-Retinoate Day & Night stands beside its matching white carton
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r-Retinoate® Day & Night

  • Brighten
  • |
  • Smooth
  • |
  • Revive
Youth Activating Cream

Our remarkable vitamin A that can be used both day and night for faster visible brightening, revitalising and smoothing results while remaining gentle.

This luxurious serum is powered by Medik8-exclusive encapsulated retinyl retinoate - proven to be 8x more powerful than standard retinol* in delivering age-defying benefits.

The multi-step-in-one formula combines retinyl retinoate with stabilised vitamin C and hyaluronic acid for profound visible improvement in skin tone, texture and radiance.

r-Retinoate Day & Night interlaces revolutionary science with a sublime sensorial experience that's highly tolerated by the most sensitive skin.


Please Note: Product packaging shown may be different to the product received due to regional variations

 
*H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93
Full Size (50ml)
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Medik8 r-Retinoate Intense Youth Activating Cream bottle displayed on a white background with a swatch of the peach-toned cream texture visible behind it.
r-Retinoate® Intense
  • Rejuvenate
  • |
  • Firm
  • |
  • Brighten
 Intense Youth Activating Cream
Full Size (50ML)
Key Benefits
Accelerated Age-Defying Results, Day & Night

Uniquely photostable retinyl retinoate doesn't lose its power in sunlight so delivers visible illuminating, smoothing & revitalising benefits both morning & night.

3-in-1 Time-Saver

Delivers all the visible wrinkle-smoothing, brightening & hydrating benefits of vitamin A, vitamin C and hyaluronic acid in one luxurious formula.

8x Stronger Than Retinol

Medik8-exclusive encapsulated retinyl retinoate is proven to be gentle yet 8x more powerful than standard retinol* in delivering visible results.

*H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93

How to Use

First-time use

If you're new to r-Retinoate Day & Night, we recommend a patch test at least 24 hours before first use. Learn how to patch test here.

Phase in application gradually. Use twice a week for the first 2 weeks, every other day/night for the next 2 weeks, then every daily.

Step 1

After cleansing, massage 2 pumps of r-Retinoate Day & Night evenly across face, neck and décolletage.

Step 2

Always use a sunscreen in the morning when using vitamin A. We recommend Advanced Day Ultimate Protect.

Uses per bottle

120
Guide to Layering
Step 1: Cleanse
Medik8 Lipid-Balance Cleansing Oil bottle stands against a white background. Golden oil droplets surround the bottle, highlighting its rich, fluid texture.
Morning
Evening
Lipid-Balance Cleansing Oil™
Full Size (140ml)
Step 2: Cleanse
Medik8 Micellar Mousse pump bottle displayed on a white background with a smear of white foam behind it, highlighting the product's texture.
Morning
Evening
Micellar Mousse™
Select a Size
Step 3: Target
A sleek white pump bottle of r-Retinoate Day & Night stands upright, with a swirl of white cream next to it.
Morning
Evening
r-Retinoate® Day & Night
Full Size (50ml)
Key Ingredients
Encapsulated Retinyl Retinoate

Patented and exclusive to Medik8, this unique vitamin A molecule is the breakthrough result of 8 years of expert research. Retinyl retinoate is proven to be 8x more powerful than classic retinol* in delivering astonishing age-defying results.

*H. Kim et al., Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative, Bioorganic & Medicinal Chemistry, 2008, 15;16(12), pp 6387-93

7% Stabilised Vitamin C (tetrahexyldecyl ascorbate)

A low-irritation form of vitamin C that delivers exceptional antioxidant protection against harmful free radical damage while supporting collagen production for a visibly even, more youthful-looking complexion.

Hyaluronic Acid

With the ability to attract and retain more than 1,000 times its own weight in water, hyaluronic acid draws moisture into the upper layers of the skin; leaving the complexion hydrated and visibly supple.

Vitamin E

A powerful antioxidant that provides additional antioxidant protection against the ageing effects of free radicals. It also helps to boost the power of vitamin C for optimum visible results.

Hyaluronic Acid

With the ability to attract and retain more than 1,000 times its own weight in water, hyaluronic acid draws moisture into the upper layers of the skin; leaving the complexion hydrated and visibly supple.

Vitamin E

A powerful antioxidant that provides additional antioxidant protection against the ageing effects of free radicals. It also helps to boost the power of vitamin C for optimum visible results.

Full List of Ingredients
r-Retinoate® Day & Night
Youth Activating Cream

Aqua (Water), Tetrahexyldecyl Ascorbate, Heptyl Undecylenate, Caprylic/Capric Triglyceride, Methylpropanediol, Polylactic Acid, Cetearyl Olivate, Sodium Polyacryloyldimethyl Taurate, Cetearyl Isononanoate, Distarch Phosphate, Tocopheryl Acetate, Sorbitan Olivate, Hydrogenated Polydecene, Retinyl Retinoate, Glycerin, Caprylyl Glycol, Sodium Hyaluronate, Cholesteryl Nonanoate, Disodium EDTA, Hydroxyacetophenone, Canola Oil, Cetearyl Alcohol, Phenylpropanol, Vanilla Planifolia (Vanilla) Fruit Extract, 3-O-Ethyl Ascorbic Acid, Sodium Metabisulfite, BHT, Sodium Hydroxide, Trideceth-10.

*Although we try our best to ensure this list of ingredients is accurate there may be product upgrades from time to time, or slight variants between different regions based on local laws, meaning the only definitive ingredient list is that which is printed on the product packaging.
  • No artificial fragrance
  • No synthetic colours
  • Paraben free
  • Alcohol free
Expert Recommended

"Combines vitamin A & vitamin C power in one luxurious age-defying serum."

DANIEL ISAACS
Chief Product Officer
A circular headshot portrait of a man with light brown hair and green eyes, smiling neutrally. He is wearing a white lab coat with 'Medik8' embroidered on the pocket and a black button-up shirt. The background is white.

"It’s easy to see why this moisturiser counts Hailey Bieber as one of its fans!"

TRACY ACHONWA
Beauty Writer - British Vogue

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Reviews

Frequently Asked Questions

Can I use r-Retinoate Day & Night if I'm pregnant or breastfeeding?
As a cosmetics company, we are unable to provide product advice in relation to medical conditions such as pregnancy or breastfeeding. We strongly recommend discussing the ingredients with your GP or midwife before use. We do, however, generally recommend avoiding vitamin A use while pregnant or breastfeeding, which is why we offer a plant-based vitamin A alternative - Bakuchiol Peptides.
How and when should I apply r-Retinoate Day & Night?
r-Retinoate Day & Night can be applied both day and night. After cleansing, massage 2 pumps evenly across the face, neck and décolletage.
r-Retinoate® Day & Night
Full Size (50ml)
Full Size (50ml)