Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost," while a geometric graphic in the corner reads "Growth Factor MP™ & NAD+ Longevity Booster."
Black backdrop with the Advanced Pro-Collagen+ Peptide Cream jar and text reading: 'Helps to increase collagen production by 45%*.' Benefit claims include firmer skin, reduced wrinkles, and increased elasticity. Asterisk notes this is from an ex vivo study.
Side-by-side 'before and after' photos of a woman over 7 days using Medik8 Advanced Pro-Collagen+ Peptide Cream. Text below reads: '7 Days to visibly reduce the depth of wrinkles.'
Close-up of a woman smiling with smooth skin. Overlay text reads: '89% agreed no new lines have formed since they started using the cream,' based on a user trial.
Black background with flowing serum texture. Text highlights three key ingredients in Medik8 Advanced Pro-Collagen+ Peptide Cream: Growth Factor MiniProtein™ for deep-set wrinkle reduction, NAD+ Longevity Booster for delaying ageing signs, and Anti-A.G.E. Peptide to reduce lines and wrinkles.
Before and after comparison showing visible improvement in smoothness and firmness after 28 days using Medik8 Advanced Pro-Collagen+ Peptide Cream. Bottom text confirms clinical results.
How to layer guide for a Medik8 skincare routine. Morning: Cleanser, Vitamin C serum, Moisturiser, SPF. Evening: Cleanser, Target serum, Retinal, Moisturiser. Visuals of each product included.
Visual comparison of two Medik8 moisturisers. Left: Advanced Night Restore for firming and smoothing wrinkles (PM use). Right: Advanced Pro-Collagen+ Peptide Cream for collagen boosting and deep wrinkle reduction (AM/PM use).
Medik8 Advanced Pro-Collagen+ Peptide Cream jar with a closed silver lid, centered on a clean white background. The frosted glass jar displays text highlighting "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost.
Advanced Pro-Collagen+ Peptide Cream
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost," while a geometric graphic in the corner reads "Growth Factor MP™ & NAD+ Longevity Booster."
Black backdrop with the Advanced Pro-Collagen+ Peptide Cream jar and text reading: 'Helps to increase collagen production by 45%*.' Benefit claims include firmer skin, reduced wrinkles, and increased elasticity. Asterisk notes this is from an ex vivo study.
Side-by-side 'before and after' photos of a woman over 7 days using Medik8 Advanced Pro-Collagen+ Peptide Cream. Text below reads: '7 Days to visibly reduce the depth of wrinkles.'
Close-up of a woman smiling with smooth skin. Overlay text reads: '89% agreed no new lines have formed since they started using the cream,' based on a user trial.
Black background with flowing serum texture. Text highlights three key ingredients in Medik8 Advanced Pro-Collagen+ Peptide Cream: Growth Factor MiniProtein™ for deep-set wrinkle reduction, NAD+ Longevity Booster for delaying ageing signs, and Anti-A.G.E. Peptide to reduce lines and wrinkles.
Before and after comparison showing visible improvement in smoothness and firmness after 28 days using Medik8 Advanced Pro-Collagen+ Peptide Cream. Bottom text confirms clinical results.
How to layer guide for a Medik8 skincare routine. Morning: Cleanser, Vitamin C serum, Moisturiser, SPF. Evening: Cleanser, Target serum, Retinal, Moisturiser. Visuals of each product included.
Visual comparison of two Medik8 moisturisers. Left: Advanced Night Restore for firming and smoothing wrinkles (PM use). Right: Advanced Pro-Collagen+ Peptide Cream for collagen boosting and deep wrinkle reduction (AM/PM use).
Medik8 Advanced Pro-Collagen+ Peptide Cream jar with a closed silver lid, centered on a clean white background. The frosted glass jar displays text highlighting "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost.
Advanced Pro-Collagen+ Peptide Cream
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Fine lines & wrinkles

Advanced Pro-Collagen+ Peptide Cream

  • Firm
  • |
  • Hydrate
  • |
  • Lift
Rejuvenating Anti-Wrinkle Moisturiser With GF MiniProteinTM & NAD+ Longevity Booster

Help increase collagen production by 45%[1] and promote optimal skin longevity with Advanced Pro-Collagen+ Peptide Cream. Expertly formulated with advanced actives that help stimulate the skin’s natural collagen production to support visible firmness, elasticity and reduce deep-set wrinkles. It delivers fast-acting, clinically proven results in just 7 days while helping to prevent the appearance of future signs of skin ageing.[2] 

Powered by regenerative science, this high-performance formula blends next-generation GF MiniProteinTM, NAD+ Longevity Booster, and Anti-A.G.E. Peptide to help visibly restore your skin’s structure for a visibly youthful, lifted and sculpted appearance.  Powerful when used alone or post-treatment. 
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 Award-winning Age-Defying Vitamin A Night Serum
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Sustainability

Provenance provides confidence for sustainability claims; helping to prevent 'green-washing' and empowering conscious consumers to purchase in line with their values. Provenance 'Proof Points' are all third party verified and evidenced through supply chains.

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The Vegan Trademark

Certified to contain no animal products or byproducts and has not been tested on animals.

Widely Recyclable Packaging

Recyclable parts: Jar, Screw Cap, Lid, Container

Brand proof points

B Corporation

Medik8 is a certified B Corporation, scoring over 80 out of 200 across Governance, Workers, Community, Environment and Customers. The certification includes a legal commitment to consider all stakeholders in decision-making. Verified every three years.

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Medik8 has SBTi approved science-based targets to reduce greenhouse gas emissions in line with limiting global warming to 1.5°C or well-below 2°C. Progress is reported publicly every year, with targets validated by the certifier and reviewed every 5 years.

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Medik8 is a Living Wage Employer — all staff are paid a wage calculated to meet the cost of living in the UK. Company wages are updated annually after new rates are announced by the Living Wage Foundation.

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In 2022 Medik8 donated £10,000 to the National Society for the Prevention of Cruelty to Children

Carbon Measured

The footprint was calculated using GHG Protocol methodology; GWP 100.

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Medik8's Innovation Centre uses electricity from 100% renewable sources.

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Medik8 carries the Made in Britain trademark — manufactured in the United Kingdom. Subject to facility verification and annual renewal.

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Key Benefits
Increased Skin Longevity

Engineered to support collagen production, the foundation of firm, resilient skin for visible strength that lasts.

Deep-Set Wrinkle Reduction

Clinically proven to visibly improve the look of wrinkles in just 1 use and reduce wrinkle depth in 7 days.[2]

Intense Hydration

Delivers deep hydration to visibly plump and soften skin, rapidly restoring the look of youthful skin volume.

Combat Skin Laxity

Clinically proven to visibly improve skin firmness in 7 days for skin more supple and youthful-looking.[2]

Lift Facial Contours

Clinically proven to visibly lift the skin and improve elasticity in 7 days to help maintain long-term skin quality.[2]

Proven Results
Before
After
Before
After
45% increase in collagen production[1]
7 days to visibly improve firmness and the look of skin fatigue[2]
7 days to visibly lift skin and reduce wrinkle depth[2]
7 days to visibly increase elasticity[2]
35% increased hydration after 1 use[2]
89% agree no new lines have formed since using the cream[3]
[1] Proven via ex vivo collagen study using Advanced Pro-Collagen+ Peptide Cream
[2] Proven via independent clinical study on Advanced Pro-Collagen+ Peptide Cream on 60 volunteers over 1 week

[3] Proven via independent consumer study on Advanced Pro-Collagen+ Peptide Cream on 113 volunteers over 4 weeks. | Please Note: Product packaging shown may be different to the product received due to regional variations.
How to Use

First-time use

If you're new to Advanced Pro-Collagen+ Peptide Cream, we recommend a patch test at least 24 hours before first use. Learn how to patch test here.

Step 1

After cleansing in the morning and evening, apply Advanced Pro-Collagen+ Peptide Cream evenly across the face, neck & décolletage. Use light upward strokes and allow the cream to fully absorb.

Step 2

After morning application, apply sunscreen. We recommend Advanced Day Ultimate Protect.

Uses per jar

60
Available Strengths

OUR AGE-DEFYING MOISTURISERS

Choose Advanced Pro-Collagen+ Peptide Cream if your goal is to boost collagen production and support overall skin longevity. It’s expertly formulated to target deeper signs of skin ageing.

Choose Advanced Night Restore if your focus is on reducing stubborn wrinkles, especially when using actives like vitamin A. It calms, nourishes and strengthens skin while you sleep.

Guide to Layering
Step 1: Cleanse
Medik8 Surface Radiance Cleanse tube displayed on a clean white background with a large, translucent gel texture smear. Text identifies it as a Resurfacing AHA/BHA Mangosteen Cleansing Gel in a 150mL size.
Morning
Evening
Surface Radiance Cleanse™
Select a Size
Step 2: Tone
Medik8 Press & Glow tonic bottle stands against a clean white background with translucent liquid droplets and a puddle, highlighting its watery texture. Text identifies the product as a 200mL
Morning
Evening
Press & Glow®
Select a Size
Step 3: Target
Liquid Peptides Advanced MP
Morning
Evening
Liquid Peptides Advanced MP
Full Size (30ml)
Step 4: Renew
Crystal Retinal®
Evening
Crystal Retinal®
Select a Strength
Step 5: Moisturise
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights
Morning
Evening
Advanced Pro-Collagen+ Peptide Cream
Select a Size
Key Ingredients
GF MiniProtein™

Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels.

NAD+ Longevity Booster

Supports skin longevity to delay visible skin ageing, preserving the skin’s structure and long-term quality.

Anti-A.G.E. Peptide (Carnosine)

Helps the prevention of new lines and wrinkles by blocking skin-damaging sugars from binding to collagen in the skin in a process called glycation.

Encapsulated Endonuclease (pronounced ‘endo-new-cle-aise’)

Helps to protect from the visible effects of sun damage and promotes skin recovery after exposure.

Anti-A.G.E. Peptide (Carnosine)

Helps the prevention of new lines and wrinkles by blocking skin-damaging sugars from binding to collagen in the skin in a process called glycation.

Encapsulated Endonuclease (pronounced ‘endo-new-cle-aise’)

Helps to protect from the visible effects of sun damage and promotes skin recovery after exposure.

Polyglutamic Acid

Works in harmony with hyaluronic acid to deeply nourish, plump and lock in moisture.

Full List of Ingredients
Advanced Pro-Collagen+ Peptide Cream
Rejuvenating Anti-Wrinkle Moisturiser With GF MiniProteinTM & NAD+ Longevity Booster

Aqua (Water), Squalane, Caprylic/Capric Triglyceride, Lavandula Angustifolia (Lavender) Flower Water, Glycerin, Dimethicone, Stearic Acid, Phytosteryl Oleate, C12-16 Alcohols, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Maltodextrin, Carnosine, Rosmarinus Officinalis (Rosemary) Water, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Ceramide NP, Linoleic Acid, Cetearyl Olivate, Palmitic Acid, Behenyl Alcohol, Tocopheryl Acetate, Collagen Amino Acids, Micrococcus Lysate, Hydrogenated Lecithin, Oligopeptide-1, Sorbitan Olivate, Helianthus Annuus (Sunflower) Sprout Extract, Xanthan Gum, Citric Acid Monohydrate, Sodium Hyaluronate, Ethylhexylglycerin, Sodium Gluconate, Sodium Polyglutamate, Acetyl Glucosamine, Hydroxyacetophenone, Phytosterols, Sodium Lauroyl Lactylate, Lecithin, Cholesterol, Ceteareth-25, Ceramide AP, Phytosphingosine, Carbomer, Cetyl Alcohol, Behenic Acid, Ceramide NS, Ceramide EOP, Ceramide EOS, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Phenoxyethanol, Ascorbyl Palmitate, Tocopherol, Glyceryl Stearate, Glyceryl Oleate, Citric Acid, Encapsulated Endonuclease, Polyglutamic Acid.

*Although we try our best to ensure this list of ingredients is accurate there may be product upgrades from time to time, or slight variants between different regions based on local laws, meaning the only definitive ingredient list is that which is printed on the product packaging.
  • Clinically proven
  • Non-comedogenic
  • Artificial fragrance-free
  • Dermatologically tested
  • Proven gentle formula
  • Certified by the vegan society
Experts Recommended

‘’We engineered this formula for multi-faceted support to help enhance and preserve collagen reserves, promoting an environment where collagen in the skin thrives; for a naturally rejuvenated and healthy looking complexion with less visible lines & wrinkles.’’

DANIEL ISAACS
Chief Product Officer
A circular headshot portrait of a man with light brown hair and green eyes, smiling neutrally. He is wearing a white lab coat with 'Medik8' embroidered on the pocket and a black button-up shirt. The background is white.

Find Your Moisturiser

Daily Radiance Vitamin C™
Morning
Daily Radiance Vitamin C™
Full Size (50ml) | £49.60
Suitable for

All Skin Types

Benefits
  • Instant brightening
  • Sun protection
  • Hydration
An open frosted glass jar of Medik8 Total Moisture Daily Facial Cream with a peak of white cream on top, set against a clean white background. Badges in the top corners indicate it is a "Daisy Beauty Awards Vinnare 2025" (Winner) and "Dermatologist Recommended."
Morning
Evening
Total Moisture Daily Facial Cream™
Full Size (50ml) | £50
Suitable for

All skin types, great for sensitive

Benefits
  • Deep moisture
  • Barrier care
Medik8 Advanced Night Restore cream jar shown open with a rich dollop of white cream peaked on top against a clean white background, highlighting its smooth, restorative texture. Black text on the jar reads "Rejuvenating Multi-Ceramide Night Cream".
Evening
Advanced Night Restore™
Full Size (50ml) | £62
Suitable for

Visible signs of ageing

Benefits
  • Nourishing
  • Firming
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost," while a geometric graphic in the corner reads "Growth Factor MP™ & NAD+ Longevity Booster."
Morning
Evening
Advanced Pro-Collagen+ Peptide Cream
Full size (50ml) | £82
Suitable for

Visible deep-set signs of ageing

Benefits
  • Rejuvenating
  • Anti-wrinkle

Complete Your Regime

Reviews

Frequently Asked Questions

What does Skin Longevity mean at Medik8?

At Medik8, skin longevity means supporting your skin to look and feel its best, not just today but for years to come. It’s our science-first approach to maintaining long-term skin quality by targeting key markers of youthful-looking, more resilient skin. Advanced Pro-Collagen+ Peptide Cream is precisely formulated with advanced actives that help stimulate the skin’s natural collagen production to support the essential building blocks of skin longevity and promote visible firmness, elasticity and reduce deep-set wrinkles.

Should I use Advanced Pro-Collagen+ Peptide Cream in the morning or at night?
Both! This collagen-supporting moisturiser is formulated for day and night use, delivering visible benefits around the clock. In the morning, it layers beautifully under SPF and makeup. At night, it works alongside your actives to deeply hydrate and help restore a visible bounce-back effect, skin resilience and firmness while you sleep.
How do I layer Advanced Pro-Collagen+ Peptide Cream in my routine?
Advanced Pro-Collagen+ Peptide Cream is your moisturising step and is designed to slot effortlessly into both your morning and evening skincare routines. In the morning, apply after your targeted serums, such as Liquid Peptides Advanced MP and C-Tetra Advanced, and then follow with sunscreen. In the evening, use after your favourite actives and vitamin A serum. Apply as your final step to lock in hydration and support overnight skin renewal. 
Does Advanced Pro-Collagen+ Peptide Cream contain fragrance or essential oils?
Advanced Pro-Collagen+ Peptide Cream does not contain any artificial fragrance or essential oils. It contains a mix of floral and herbal waters that lend a subtle aroma to the overall fragrance.
Does the 'GF' in GF MiniProtein™ (found in Liquid Peptides Advanced MP, Advanced Pro-Collagen+ Peptide Cream, and Exo-PDRN Prismatic+) stand for Growth Factor?

Yes, the 'GF' on our packaging stands for Growth Factor MiniProtein™, a next-generation form of growth factor in skincare. Its small molecular size makes it more advanced than traditional options like TGF, EGF, and IGF, allowing it to unlock previously untapped cosmetic effectiveness within the skin's anti-ageing pathways.

Is Advanced Pro-Collagen+ Peptide Cream suitable for use during pregnancy or nursing?
Unfortunately, as a cosmetic brand, we are unable to provide specific medical advice relating to our products. We would strongly advise speaking with your GP or midwife so that they can give you an accurate recommendation. The full ingredients list for each of our products can be found on the product pages of the Medik8 website. As general guidance, Advanced Pro-Collagen+ Peptide Cream does not contain any ingredients which we would recommend avoiding during pregnancy unless advised by your doctor.  For clinically proven visible wrinkle reduction, it’s a great choice while avoiding retinoids or high-strength exfoliating acids that are not recommended during pregnancy.
Is Advanced Pro-Collagen+ Peptide Cream suitable for sensitive skin?
Yes, Advanced Pro-Collagen+ Peptide Cream is formulated for sensitive skin.
Can I use Advanced Pro-Collagen+ Peptide Cream with Liquid Peptides Advanced MP?

Absolutely. Liquid Peptides Advanced MP and Advanced Pro-Collagen+ Peptide Cream make an ideal collagen-boosting duo. Use Liquid Peptides Advanced MP to instantly target expression lines and build visible deep-set wrinkle reduction over time. Reach for Advanced Pro-Collagen+ Peptide Cream to trigger the foundations of skin longevity to achieve visibly stronger, smoother and revitalised skin.

Can I use Advanced Pro-Collagen+ Peptide Cream with Crystal Retinal?
Absolutely. Advanced Pro-Collagen+ Peptide Cream and Crystal Retinal make an ideal age-defying duo. Crystal Retinal is our iconic retinoid serum which targets all signs of skin ageing; wrinkles, firmness, elasticity, dark spots, skin texture and more.  Follow with Advanced Pro-Collagen+ Peptide Cream to trigger the foundations of skin longevity with results starting in just 7 days.[1]
Is Advanced Pro-Collagen+ Peptide Cream suitable for sensitive skin?
Yes, Advanced Pro-Collagen+ Peptide Cream is formulated for sensitive skin.
Can I use Advanced Pro-Collagen+ Peptide Cream with Liquid Peptides Advanced MP?

Absolutely. Liquid Peptides Advanced MP and Advanced Pro-Collagen+ Peptide Cream make an ideal collagen-boosting duo. Use Liquid Peptides Advanced MP to instantly target expression lines and build visible deep-set wrinkle reduction over time. Reach for Advanced Pro-Collagen+ Peptide Cream to trigger the foundations of skin longevity to achieve visibly stronger, smoother and revitalised skin.

Can I use Advanced Pro-Collagen+ Peptide Cream with Crystal Retinal?
Absolutely. Advanced Pro-Collagen+ Peptide Cream and Crystal Retinal make an ideal age-defying duo. Crystal Retinal is our iconic retinoid serum which targets all signs of skin ageing; wrinkles, firmness, elasticity, dark spots, skin texture and more.  Follow with Advanced Pro-Collagen+ Peptide Cream to trigger the foundations of skin longevity with results starting in just 7 days.[1]
Does the 'GF' in GF MiniProtein™ (found in Liquid Peptides Advanced MP, Advanced Pro-Collagen+ Peptide Cream, and Exo-PDRN Prismatic+) stand for Growth Factor?

Yes, the 'GF' on our packaging stands for Growth Factor MiniProtein™, a next-generation form of growth factor in skincare. Its small molecular size makes it more advanced than traditional options like TGF, EGF, and IGF, allowing it to unlock previously untapped cosmetic effectiveness within the skin's anti-ageing pathways.
Advanced Pro-Collagen+ Peptide Cream
Full size (50ml)
Select a Size