A group of researchers from the Prefectural Hiroshima University in Japan have published findings proving that Tetrahexadecyl Ascorbate (known as C-Tetra) is highly effective at preventing photo-ageing. It was also established that C-Tetra increased collagen synthesis within skin and therefore its potential for use in anti-ageing skincare products has been firmly established.

The researchers published their findings in the March 2009 edition of the Journal of Cell Biochemistry. It was found that by administering 10-50 microM of C-Tetra to human fibroblasts and then irradiating them with UVA, the cells were protected from UV damage. The tests used several markers to evaluate C-Tetra performance including the successful repression of MMPs and the repression of p53 gene expression (a hallmark of UV induced damage).

Importantly, C-Tetra also suppressed melanocyte proliferation and interleukin-1α and prostaglandin E2, all factors strongly implicated in skin cancer caused by UV radiation. (Ochiai Y. et. al. 2006)

The potent form of vitamin C has been used by Medik8 to create two topical serums designed to help prevent sun-induced damage to the skin. The serums also trigger collagen synthesis, increase the skin’s elasticity and density, improve the skin’s texture and will brighten the complexion.

“Medik8® is the only company to offer C-Tetra in an unadulterated serum format and with a patent-pending delivery vehicle which enhances both stability and transcuteneous absorption. Our professional-only range includes C-Tetra and CE-Tetra with 3% and 7% of Tetrahexadecyl Ascorbate respectively,” states Marianne Stewart, International Sales Director from Pangaea Laboratories, the manufacturers of Medik8®.

These papers independently confirm Medik8’s own findings. Pharmacologist and Medik8 founder Elliot Isaacs. He commented, “We are extremely satisfied with the conclusions of this respected Japanese scientific group whose findings corroborate and exceed our own research data into the activity of Tetrahexadecyl Ascorbate.” Mr. Isaacs added, “The repression of p53 gene expression discovered by Professor Xiao et al. demonstrates the potential anti-cancer protection long suspected of this ingredient. This is very exciting news for Medik8 and all our customers.”

By Vicky Eldridge

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